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1.
Nat Commun ; 15(1): 3903, 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38724537

RESUMO

Tropical Cyclones (TCs) are devastating natural disasters. Analyzing four decades of global TC data, here we find that among all global TC-active basins, the South China Sea (SCS) stands out as particularly difficult ocean for TCs to intensify, despite favorable atmosphere and ocean conditions. Over the SCS, TC intensification rate and its probability for a rapid intensification (intensification by ≥ 15.4 m s-1 day-1) are only 1/2 and 1/3, respectively, of those for the rest of the world ocean. Originating from complex interplays between astronomic tides and the SCS topography, gigantic ocean internal tides interact with TC-generated oceanic near-inertial waves and induce a strong ocean cooling effect, suppressing the TC intensification. Inclusion of this interaction between internal tides and TC in operational weather prediction systems is expected to improve forecast of TC intensity in the SCS and in other regions where strong internal tides are present.

2.
Molecules ; 29(8)2024 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-38675549

RESUMO

Derived from hazelnuts, hazel leaf has been utilized in traditional folk medicine for centuries in countries such as Portugal, Sweden, and Iran. In our previous investigations, we conducted a preliminary assessment of the hazel leaf polyphenol extract (referred to as ZP) and identified nine compounds, such as kaempferol and chlorogenic acid, in its composition. ZP has shown promising properties as an antioxidant and anti-inflammatory agent. Our research has revealed that ZP has protective effects against cisplatin-induced acute kidney injury (AKI). We conducted a comprehensive examination of both the pathological and ultrastructural aspects and found that ZP effectively ameliorated renal tissue lesions and mitigated mitochondrial damage. Moreover, ZP significantly suppressed malondialdehyde levels while increasing glutathione and catalase concentrations in the kidneys of AKI-induced mice. ZP decreased the number of apoptotic cells and decreased pro-apoptotic protein expression in the kidneys of mice and human renal tubular epithelial cells (HK-2). Furthermore, treatment with ZP increased the levels of proteins marking anti-ferroptosis, such as GPX4, FTH1, and FSP1, in experiments both in vivo and in vitro. We elucidated the underlying mechanisms of ZP's actions, revealing its inhibitory effect on Yap phosphorylation and its regulation of Lats expression, which exert a protective influence on the kidneys. Furthermore, we found that inhibiting the Hippo pathway compromised ZP's nephroprotective effects in both in vitro and in vivo studies. In summary, this research shows that ZP exhibits renoprotective properties, effectively reducing oxidative damage, apoptosis, and ferroptosis in the kidneys by targeting the Hippo pathway.


Assuntos
Injúria Renal Aguda , Cisplatino , Ferroptose , Via de Sinalização Hippo , Extratos Vegetais , Folhas de Planta , Polifenóis , Transdução de Sinais , Animais , Injúria Renal Aguda/tratamento farmacológico , Injúria Renal Aguda/metabolismo , Injúria Renal Aguda/induzido quimicamente , Ferroptose/efeitos dos fármacos , Cisplatino/efeitos adversos , Polifenóis/farmacologia , Polifenóis/química , Camundongos , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Humanos , Transdução de Sinais/efeitos dos fármacos , Folhas de Planta/química , Proteínas Serina-Treonina Quinases/metabolismo , Masculino , Linhagem Celular , Antioxidantes/farmacologia , Apoptose/efeitos dos fármacos , Modelos Animais de Doenças , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Estresse Oxidativo/efeitos dos fármacos
3.
Sci Total Environ ; 912: 169238, 2024 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-38072268

RESUMO

The substitution of chemical nitrogen fertilizer with manure holds the potential for a synergistic rise in wheat grain yield and protein concentration, while minimizing residual nitrate in soil. We conducted a 6-year field fertilization experiment including two manure treatments (with or without) and five nitrogen applications rates (0, 60, 120, 180 and 240 kg ha-1). The study investigated the impact of single chemical nitrogen (CN) and manure substitution for nitrogen fertilizer (MN) on the grain yield (GY), grain protein concentration (GPC), plant nitrogen uptake (PNupt) and plant nitrogen requirement (PNR) of wheat, and the dynamic change of soil nitrate-N. The findings revealed that: (1) the MN demonstrated a greater advantage over CN, as evidenced by a 13.4-16.0 % increase in GY, a 2.6-3.8 % increase in GPC, a 7.2-15.7 % increase in PNupt and a 1.5-4.7 % reduction in PNR. (2) Soil nitrate accumulation (SNA) significantly increased when fertilizer rates ≥180 kg ha-1 and the peak annually shifted to deeper layer. The MN increased the SNA0-100 by 20.9-21.8 %, but significantly reduced SNA0-200 by 11.8-13.5 % compared with the CN. Topsoil nitrate content (SNC0-20) can be adopted as a substitute for SNA0-100 to make the fertilization schedule convenient. (3) Regression analysis revealed (taking the MN for example) that the optimum N rates for the maximum GY (5417 kg ha-1) and GPC (15.3 %) were 164 and 211 kg N ha-1, respectively. The nitrate-N safety threshold was 62 kg ha-1 at the fertilizer rate of 89 kg N ha-1. Based on this, nitrogen fertilizer input reduced by 44.8-57.2 % and SNA0-200 by 17.9-33.6 %, with achieving 91.8-95.0 % of maximum GY and 89.7-92.9 % of maximum GPC. Substituting manure for nitrogen fertilizer achieved the potential of maintaining the grain yield and protein concentration while the minimization in soil nitrate residue. This study offers a feasible way for fertilization recommendation and nitrate residue controlling in dry farming.


Assuntos
Nitratos , Triticum , Nitratos/análise , Fertilizantes/análise , Esterco , Agricultura , Solo/química , Grão Comestível/química , Nitrogênio/análise , Fertilização
4.
Front Psychol ; 14: 1047544, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36874821

RESUMO

Purpose: The study aimed to research the promoting effects of Tai Chi exercise on working memory capacity and emotional regulation ability among college students. Methods: Fifty-five participants were recruited and randomly divided into the Tai Chi group and control group. The Tai Chi group had a 12-week Tai Chi training to implement intervention, while the control group performed non-cognitive traditional sports with the same exercise intensity as the Tai Chi group. The visual 2-back test of action pictures and the Geneva emotional picture system test were performed before and after the trial, which aimed to examine whether the action memory of Tai Chi training can improve individuals' working memory capacity and emotion regulation ability. Results: After 12 weeks, a significant difference was observed in Accuracy Rate (AR) (F = 54.89, p ≤ 0.001) and Response Time (RT) (F = 99.45, p ≤ 0.001) of individuals' Visual Memory Capacity between the Tai Chi group and the control group. Significant effects in Time (F = 98.62, p ≤ 0.001), Group (F = 21.43, p ≤ 0.001), and Interaction (Groups × time; F = 50.81, p ≤ 0.001) on Accuracy Rate (AR) of the Visual Memory Capacity were observed. The same effect was observed again on the Response Time (RT) of the Visual Memory Capacity, Time (F = 67.21, p ≤ 0.001), Group (F = 45.68, p ≤ 0.001), Interaction (groups × time; F = 79.52, p ≤ 0.001). Post-hoc analysis showed that at the end of 12 weeks, the participants in the Tai Chi group had significantly higher Visual Memory Capacity than those in the control group (p < 0.05).After 12 weeks, valence difference (F = 11.49, p ≤ 0.001), arousal difference (F = 10.17, p ≤ 0.01), and dominance difference (F = 13.30, p ≤ 0.001) in the emotion response were significantly different between the control group and the Tai Chi group. The effect of valence differences in Time (F = 7.28, p < 0.01), Group (F = 4.16, p < 0.05), and Time*Group (F = 10.16, p < 0.01), respectively, was significant in the Tai Chi group after 12-week intervention. Post hoc analysis showed valence swings in the Tai Chi group were significantly lower than that in the control group (p < 0.05); The effect of arousal difference in Time (F = 5.18, p < 0.05), Group (F = 7.26, p < 0.01), Time*Group (F = 4.23, p < 0.05), respectively, was significant in the Tai Chi group after 12-week intervention. Post hoc analysis showed arousal fluctuations in the Tai Chi group was significantly lower than that in the control group too (p < 0.01); As the same, the effect of dominance differences in Time (F = 7.92, p < 0.01), Group (F = 5.82 p < 0.05) and Time*Group (F = 10.26, p < 0.01), respectively was significant in the Tai Chi group. Dominance swings in the Tai Chi group were significantly lower than that in the control group (p < 0.001). Conclusion: The data support our speculation that action memory training in Tai Chi exercise may improve individuals' working memory capacity, and then improve their emotion regulation ability, which has provided insightful information for customized exercise programs for emotion regulation in adolescents. Thus, we suggest those adolescents who are experiencing volatile moods and poor emotion regulation attend regular Tai Chi classes, which could contribute to their emotional health.

5.
J Safety Res ; 82: 417-429, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-36031272

RESUMO

INTRODUCTION: Due to globalization and the acceleration of cross-border exchanges, cross-border risk behaviors have received widespread attention. Previous research has concluded that foreign cross-border drivers engage in relatively more risk-taking behavior patterns and are likely to experience a higher crash rate or be more inclined to cause severe crashes. However, there is little evidence on the comparison of drivers who belong to the same ethnic group driving across within-country borders. METHOD: Based on the cross-border motor-vehicle crash reports in 2006-2010 from the Road Traffic Accident Database of the China Ministry of Public Security, this paper examines the risk factors of being at fault and getting killed or seriously injured in cross-border traffic crashes and casual paths toward crash liability and injury severity for Hong Kong and Macao drivers driving in the Chinese mainland. RESULTS: There are extremely complex factors behind drivers from Hong Kong and Macao causing at-fault crashes or sustaining fatal and serious injuries in the Chinese mainland. Factors such as gender, age, illumination, and weather conditions do not individually affect the risk of driver at-fault crashes or severe casualties in the crashes among Hong Kong and Macao drivers driving in the Chinese mainland. Nonetheless, collectively, these factors influence them along with different vehicle types, roads, and environmental factors. CONCLUSIONS: This paper provides more theoretical findings for understanding the compound effect of multiple risk factors involving cross-border at-fault crashes or serious casualties. The conclusions of this research are valuable as representative references for cross-border risk management policies. PRACTICAL APPLICATIONS: To reduce the effects of different factors on cross-border risky driving behaviors and/or injurious crashes, various measures should be focused on, including specialized driver training, enhancement of the roads/environment, development of effective road safety campaigns, and directives facilitating cross-border cooperation in the field of road safety.


Assuntos
Acidentes de Trânsito , Condução de Veículo , Hong Kong , Humanos , Modelos Logísticos , Macau , Assunção de Riscos
6.
Artigo em Inglês | MEDLINE | ID: mdl-34484394

RESUMO

OBJECTIVE: The aim of this study was to examine the promoting effects of mindfulness training on female college students' mental toughness in endurance exercise. METHODS: A cluster sampling method was used to select 60 female college students as subjects. Based on the body mass index (BMI), stratified randomization was used to divide them into the mindfulness-training group and the control group. Participants in mindfulness-training group had an 8-week mindfulness training, while participants in control group waited. Before and after training, Five Facet Mindfulness Questionnaire (FFMQ) and Connor-Davidson Resilience Scale (CD-RISC) were used for pretest and posttest, and paired t-test and covariance analysis were performed on pretest and posttest between-group data. RESULTS: (1) Paired t-test results showed the posttest scores (26.67 ± 3.56; 20.97 ± 3.66; 126.53 ± 8.59) of the three dimensions of description, nonresponse and FFMQ total score of the mindfulness-training group were higher than the pretest scores (25.53 ± 3.74; 19.23 ± 3.59; 121.43 ± 6.78). Statistical significance was shown in their differences (t = -2.25; -2.70; -3.25, p < 0.05). However, there was no statistical significance in the pretest and posttest of control group. The covariance analyses showed the posttest scores of the mindfulness-training group in three dimensions of description, nonresponse, and FFMQ were higher than the posttest scores of the control group. Statistical significance was shown in their differences (F = 6.55; 6.08; 5.91; p < 0.05). (2) Paired t-test showed posttest scores (46.50 ± 5.93; 30.40 ± 3.75; 15.00 ± 2.34) were significantly higher than pretest scores (42.60 ± 7.68; 26.50 ± 4.32; 12.87 ± 2.51) in all dimensions of the mental toughness of the mindfulness-training group. Statistical significance was shown in their differences (t = -3.135, -4.765, -4.922, p < 0.01). However, there was no significant difference in the pretest and posttest scores in all dimensions of the mental toughness of the control group. The covariance analysis showed that the posttest scores of all dimensions of the mental toughness of the mindfulness-training group were higher than those of the control group, and the differences were statistically significant (F = 11.133, 12.101, 16.053, all p < 0.001). (3) Paired t-test showed that the posttest score of the mindfulness-training group on exercise intensity perception immediately after 800-meter endurance run (5.67 ± 2.61) was lower than the pretest score (7.03 ± 1.24) and the difference was statistically significant (t = 4.18, p < 0.001), while the difference was not statistically significant in the control group. The covariance analysis showed that the posttest score of the mindfulness-training group on exercise intensity perception was lower than that of the control group, and the difference was statistically significant (F = 15.81, p < 0.001). CONCLUSION: Mindfulness training improved the level of female college students' mindfulness and mental toughness in their endurance sports, while reducing the fatigue feeling of female college students in endurance sports.

7.
Sci Rep ; 9(1): 556, 2019 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-30679478

RESUMO

It is reported that turbulent mixing is enhanced in the South China Sea (SCS), and it is highly variable in both space and time. Generation and breaking of internal tides has been identified as the main process to drive turbulent mixing in the SCS, while the contributions from other processes are not clear enough. Here we investigate the potential contribution from mesoscale eddies to turbulent mixing in the SCS using a high resolution numerical simulation. Our results show that mesoscale eddies in the SCS effectively dissipate over complex rough topography and indicate that the generation of submesoscale motions and lee waves are two pathways for the transfer of mesoscale eddy energy down to small dissipation scales. The energy loss from mesoscale eddies near the Xisha Islands is estimated to be sufficient to sustain turbulent kinetic energy dissipation rate of O (10-8) W/kg. This study suggests an alternative and potentially efficient mechanism to internal tides for the local maintenance of turbulent mixing in the SCS.

8.
Sci Rep ; 8(1): 14334, 2018 09 25.
Artigo em Inglês | MEDLINE | ID: mdl-30254370

RESUMO

One-year time series of current velocities and hydrographic parameters based on four deep moorings deployed east of the Luzon Strait are employed to study the deep current at the western boundary (DCWB) of the northern Philippine Basin. While the mean current is relatively weak, the DCWB is highly variable on an intraseasonal time scale, with dominant periods ranging between 30 and 80 days. During the period of observation (October 2011-October 2012), the DCWB reversed its direction at early April, and pointed southward (-2.4 cm/s) in summer/autumn and northward (1.7 cm/s) in winter/spring. This annual reversal of the DCWB is consistent with the water property distribution in the deep Philippine Basin, with relatively cold and fresh water to the north and relatively warm and salty water to the south. The moored time series also allow for discussion on the stratification of the deep Luzon Strait, which indicates the lower interface of Pacific deep water capable of furnishing the deepwater overflow in the Luzon Strait.

9.
Sci Rep ; 7(1): 9303, 2017 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-28839249

RESUMO

Deep western boundary current (DWBC) was observed for the first time by an array of 6 current meter moorings southeast of the Zhongsha Islands in the South China Sea (SCS) deep basin during the period from August 2012 to January 2014. In the mean, the DWBC in the SCS flows southwestward with core velocity of 2.0 cm/s and a volume transport of 1.65 Sv (1 Sv = 1 × 106 m3/s). Its temporal variability is dominated by intraseasonal fluctuations with period around 90 days. The main axis of the DWBC, characterized by a low temperature core, tends not to shift with the 90-day fluctuation.

10.
Sci Rep ; 6: 30041, 2016 07 21.
Artigo em Inglês | MEDLINE | ID: mdl-27444063

RESUMO

With characteristics of large amplitude and strong current, internal solitary wave (ISW) is a major hazard to marine engineering and submarine navigation; it also has significant impacts on marine ecosystems and fishery activity. Among the world oceans, ISWs are particular active in the northern South China Sea (SCS). In this spirit, the SCS Internal Wave Experiment has been conducted since March 2010 using subsurface mooring array. Here, we report an extreme ISW captured on 4 December 2013 with a maximum amplitude of 240 m and a peak westward current velocity of 2.55 m/s. To the authors' best knowledge, this is the strongest ISW of the world oceans on record. Full-depth measurements also revealed notable impacts of the extreme ISW on deep-ocean currents and thermal structures. Concurrent mooring measurements near Batan Island showed that the powerful semidiurnal internal tide generation in the Luzon Strait was likely responsible for the occurrence of the extreme ISW event. Based on the HYCOM data-assimilation product, we speculate that the strong stratification around Batan Island related to the strengthening Kuroshio may have contributed to the formation of the extreme ISW.

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